Atlas of Hematologic Neoplasms
Atlas of Hematologic Neoplasms, pdf
Atlas of Hematologic Neoplasms
Due to its rapid development in
recent years, hematopathology has
become a very complicated
discipline. The current development
is mainly in two aspects: the new
classification of lymphomas and
leukemias and the new techniques.
The Revised European-American
Classification of Lymphoid Neoplasms
(REAL classification) and the World
Health Organization (WHO)
classification of hematologic
neoplasms require not only
morphologic criteria but also
immunophenotyping and molecular
genetics for the diagnosis of
hematologic tumors.
Immunophenotyping is performed by
either flow cytometry or
immunohistochemistry. There are many
new monoclonal antibodies and new
equipments accumulated in recent
years that make immunophenotyping
more or more accurate and helpful.
There are even more new techniques
invented in recent years in the
field of molecular genetics. In
cytogenetics, the conventional
karyotype is supplemented and
partially replaced by the
fluorescence in situ hybridization
(FISH) technique. The current
development of gene expression
profiling is even more powerful in
terms of subtyping the hematologic
tumors, which may help guide the
treatment and predict the prognosis.
In molecular biology, the tedious
Southern blotting technique is
largely replaced by polymerase chain
reaction (PCR). The recent
development in reverse-transcriptase
PCR and quantitative PCR makes these
techniques even more versatile.
Because of these new developments,
hematopathology has become too
complicated to handle by a general
pathologist. Many hospitals have to
hire a newly trained
hematopathologist to oversee
peripheral blood, bone marrow and
lymph node examinations. These young
hematopathologists are geared to the
new techniques, but most of them are
inexperienced in morphology. No
matter how well-trained a
hematopathologist is, he or she
still needs to see enough cases so
that they can recognize the
morphology and use the new
techniques to substantiate the
diagnosis. In other words,
morphology is still the basis for
the diagnosis of lymphomas and
leukemias.
Therefore, a good
color atlas is the most helpful tool
for these young hematopathologists
and for the surgical pathologists
who may encounter a few cases of
hematologic tumors from time to
time. In a busy daily practice, it
is difficult to refer to a
comprehensive hematological textbook
all the time. There are a few
hematologic color atlases on the
market to show the morphology of the
normal blood cells and hematologic
tumor cells. These books are helpful
but not enough, because tumor cell
morphology is variable from case to
case and different kinds of tumor
cells may look alike and need to be
differentiated by other parameters.
The best way to learn morphology is
through the format of clinical case
studies. This format is also
consistent with the daily practice
of hematopathologists and with the
pattern in all the specialty board
examinations. Therefore, it is a
good learning tool for the pathology
residents, hematology fellows as
well as medical students.
This
proposed book will present 83
clinical cases with clinical
history, morphology of the original
specimen and a list of differential
diagnoses. This is followed by
further testing with pictures to
show the test results. At the end, a
correct diagnosis is rendered with
subsequent brief discussion on how
the diagnosis is achieved. A few
useful references will be cited and
a table will be provided for
differential diagnosis in some
cases.
The major emphasis is the
provision of 500 color photos of
peripheral blood smears, bone marrow
aspirates, core biopsy, lymph node
biopsy and biopsies of other solid
organs that are involved with
lymphomas and leukemias. Pictures of
other diagnostic parameters, such as
flow cytometric histograms,
immunohistochemical stains,
cytogenetic karyotypes, fluorescence
in situ hybridization and polymerase
chain reaction, will also be
included.
A comprehensive
approach with consideration of
clinical, morphological,
immunophenotypic and molecular
genetic aspects is the best way to
achieve a correct diagnosis. After
reading this book, the reader will
learn to make a diagnosis not only
based on the morphology alone but
also in conjunction with other
parameters.
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